Introduction: What is chemical genomics?
It is a study using high-throughput screening of small molecules to identify new drug targets and genes in biological pathway. [1] There are two approaches in chemical genomics: forward (phenotypic) screening and reverse (target-based) screening.
In the forward screening, you treat the cells or organisms with a library of chemical compounds and then observe the phenotypes. This allows you to identify the key chemical compounds that causes desired phenotypic changes.
In the reverse screening, you have a known protein or target of interest, then treat the cells with a library compounds to identify the compounds that specifically binds to this protein.
In the forward screening, you treat the cells or organisms with a library of chemical compounds and then observe the phenotypes. This allows you to identify the key chemical compounds that causes desired phenotypic changes.
In the reverse screening, you have a known protein or target of interest, then treat the cells with a library compounds to identify the compounds that specifically binds to this protein.
Discussion
Currently there is no chemical compounds that can rescue the AMD phenotype caused by HTRA1 mutation. The small molecule screening will provide us with a powerful tool to identify the potential drugs that targets various pathways that contributes to the angiogenesis and druses formation in AMD.
Reference
[1] Wikipedia Contributors. (2023, December 9). Chemogenomics. Retrieved March 28, 2024, from Wikipedia website: https://en.wikipedia.org/wiki/Chemogenomics
[2] Schmidt, M. F. (2022). From Genomic Research to Chemical Biology. Springer EBooks, 19–29. https://doi.org/10.1007/978-3-662-64412-6_4
[1] Wikipedia Contributors. (2023, December 9). Chemogenomics. Retrieved March 28, 2024, from Wikipedia website: https://en.wikipedia.org/wiki/Chemogenomics
[2] Schmidt, M. F. (2022). From Genomic Research to Chemical Biology. Springer EBooks, 19–29. https://doi.org/10.1007/978-3-662-64412-6_4