Introduction: what are protein modifications?
Post-translational modifications in proteins (PTMs) are covalent addition events that increase the functional diversity of the proteomics, including phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis. [1] PTMs are important for understanding the changes in protein functions including chemical and physical properties and stability.
Protein modifications of HTRA1
Below are the putative phosphorylation sites in human HTRA1 protein obtained from NetPhos and PhosphoSitePlus.
Discussions
The putative phosphorylation sites in HTRA1 are important for understanding PTMs of the proteins. There is no obvious signal for the predicted phosphorylation in IGFBP domain, which mainly functions as protein binding domain. Overall, there is limited phosphorylation sites in HTRA1 protein.
Reference
[1]Overview of Post-Translational Modification | Thermo Fisher Scientific - US. (2024). Retrieved April 30, 2024, from Thermofisher.com website: https://www.thermofisher.com/us/en/home/life-science/protein-biology/protein-biology-learning-center/protein-biology-resource-library/pierce-protein-methods/overview-post-translational-modification.html